INHALATION DOSAGE FORM OF RAPAMYCIN FOR TREATING PULMONARY HYPERTENSION Russian patent published in 2020 - IPC A61K31/436 A61K45/06 A61K9/12 A61K9/14 A61P9/02 A61P9/08 

FIELD: medicine.

SUBSTANCE: present invention relates to a method of treating or preventing pulmonary arterial hypertension (PAH) in a human, the method comprising administering to a subject by inhalation a pharmaceutical aerosol composition in the form of a dry powder containing rapamycin microparticles, where the rapamycin particles have a weight average aerodynamic diameter (MMAD) of 1 to 5 mcm, and carrier particles, where the dosage form is effective for delivering a therapeutic amount of rapamycin to the lungs, where composition contains 5 to 500 mcg of rapamycin and ratio of rapamycin and carrier in powder is 0.5 to 2 % by weight.

EFFECT: technical result of the present invention is the possibility of safe delivery of rapamycin to the lungs in the form of a dry powder containing rapamycin microparticles, by inhalation, reducing or eliminating toxicity and adverse side effects.

16 cl, 11 ex, 16 tbl, 9 dwg