FIELD: medicine.
SUBSTANCE: present invention refers to a cure for treating lung cancer or chronic lung disease in a human. Method involves administering a pharmaceutical aerosol composition in the form of a dry powder of micronised rapamycin, carrier particles and one or more optional excipients by inhalation to a subject. Micronised rapamycin consists of particles with mass median aerodynamic diameter (MMAD) from 1 to 5 mcm. Total daily dose of rapamycin administered once a day to subject is 50 to 250 mcg. Preferably, the carrier contains a mixture of two different carriers, most preferably, the carrier consists of a mixture of two different lactose carriers.
EFFECT: method according to the invention provides high local concentration of rapamycin in lung tissue, which is achieved with a relatively low concentration of rapamycin.
9 cl, 9 dwg, 15 tbl, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
| RAPAMYCIN FOR TREATING LYMPHANGIOLEIOMYOMATOSIS | 2014 |
|
RU2707285C2 |
| INHALATION DOSAGE FORM OF RAPAMYCIN FOR TREATING PULMONARY HYPERTENSION | 2015 |
|
RU2732908C2 |
| INHALATION COMPOSITIONS CONTAINING MONTELEUKAST ACID AND PDE-4 INHIBITOR OR INHALATION CORTICOSTEROID | 2008 |
|
RU2470639C2 |
| AEROSOL PHARMACEUTIC COMPOSITION, BOTTLE FOR STORAGE AND DELIVERY OF AEROSOL PHARMACEUTIC COMPOSITION, METHOD OF TREATMENT OF RESPIRATORY DISEASES, COMPOSITION PREPARATION METHOD | 1993 |
|
RU2120285C1 |
| METHODS OF TREATING FUNGAL INFECTIONS | 2019 |
|
RU2820457C2 |
| COMPOSITIONS FOR TREATING PARKINSON'S DISEASE | 2008 |
|
RU2484823C2 |
| AEROSOL FLUOROCHINOLONES AND THEIR APPLICATIONS | 2006 |
|
RU2428986C2 |
| SYSTEMS AND METHODS FOR DRY POWDER DRUGS DELIVERY | 2011 |
|
RU2531455C2 |
| DRY POWDER DRUG DELIVERY SYSTEMS AND METHODS | 2013 |
|
RU2650035C2 |
| NANOPARTICLES EASILY PENETRATING INTO MUCOSA OR INDUCING LESS INFLAMMATION | 2012 |
|
RU2631599C2 |
