METHODS AND COMPOSITIONS FOR TREATING PULMONARY HYPERTENSION Russian patent published in 2024 - IPC A61K9/14 A61K31/436 A61K47/42 A61P9/12 

FIELD: medicine; pharmaceutics.

SUBSTANCE: group of inventions relates to medicine and pharmaceutics. Objects 1 and 3 are embodiments of a method of treating pulmonary hypertension in an individual having pulmonary hypertension, comprising administering to the individual a composition comprising nanoparticles comprising rapamycin and a protein carrier albumin, where the rapamycin dose in the composition is from 1 to 10 mg/m², where the nanoparticle composition is administered not more often than once a week, where the individual is a person resistant, refractory or recurrent to at least two previous pulmonary hypertension therapies. Object 2 is a method for improving the results of the six-minute walking distance test (6MWD) in an individual suffering from pulmonary hypertension, where the individual is a person resistant, refractory or recurrent to at least two previous pulmonary hypertension therapies.

EFFECT: reduction of pressure in pulmonary vessels (PVR), increase of cardiac output (CO), improvement of 6-minute walking (6MWD) and reduction of functional class according to WHO classification.

22 cl, 22 dwg, 11 tbl, 5 ex