FIELD: biotechnology.
SUBSTANCE: what is presented is a chimeric antigenic receptor (CAR) designed for depletion of CAR-targeted immune cells. CAR contains an extracellular binding domain which contains scFv formed by a VH chain and a VL chain, CD8 alpha hinge, a transmembrane domain containing a transmembrane region/regions CD8 alpha, and an intracellular domain comprising a CD3 zeta signal domain and a costimulatory domain of 4-1BB. Said extracellular binding domain contains at least one MAt-specific epitope. Invention also relates to production of CAR, to production and use of a constructed T-cell or NK-cell expressing on its cell surface CAR under the invention.
EFFECT: invention provides effective MAt-directed depletion of T-cells expressing said CAR.
30 cl, 22 dwg, 4 tbl, 7 ex
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