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(19)

(11)

2 731 543

(13)

(51)

IPC

C07K14/725(2006-01-01)

C07K16/28(2006-01-01)

C12N15/12(2006-01-01)

C12N15/13(2006-01-01)

C12N15/63(2006-01-01)

C12N5/10(2006-01-01)

A61K35/17(2015-01-01)

A61P35/00(2006-01-01)

C07K19/00(2006-01-01)

(21) (22)

Application

2017129592, 2016-01-25

(24)

Start date

2016-01-25

(22)

Actual filing date

2016-01-25

(45)

Published

2020-09-04

(72)

Inventor

Smit DzhuliannaValton DzhulienDzhyullerat AleksandreDyushato FilippSasu Barbra DzhonsonRadzhpal Arvind

(73)

Holder

Cellectis

ANTI-CLL1-SPECIFIC SINGLE-CHAIN CHIMERIC ANTIGENIC RECEPTORS (SCCAR) FOR CANCER IMMUNOTHERAPY Russian patent published in 2020 - IPC C07K14/725 C07K16/28 C12N15/12 C12N15/13 C12N15/63 C12N5/10 A61K35/17 A61P35/00 C07K19/00

Abstract RU 2731543 C2

FIELD: biotechnology.

SUBSTANCE: disclosed is a CLL1-specific chimeric antigen receptor (CAR) capable of redirecting the specificity and reactivity of immune cells to CLL1-positive cells. Invention also relates to CAR coding polynucleotide molecules, to production and use of a constructed T-cell expressing on its cell surface CAR under the invention.

EFFECT: constructed immune cells endowed with said CAR are most suitable for immunotherapy in treating cancer, particularly leukemia.

45 cl, 4 dwg, 11 tbl, 2 ex

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RU 2 731 543 C2

Authors

Smit Dzhulianna

Valton Dzhulien

Dzhyullerat Aleksandre

Dyushato Filipp

Sasu Barbra Dzhonson

Radzhpal Arvind

Dates

2020-09-04—Published

2016-01-25—Filed