Show metadata Hide metadata

(19)

(11)

2 734 418

(13)

(51)

IPC

C07D495/04(2006-01-01)

A61K31/519(2006-01-01)

A61K45/06(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2018102365, 2016-06-22

(24)

Start date

2016-06-22

(22)

Actual filing date

2016-06-22

(45)

Published

2020-10-16

(72)

Inventor

Slavik ZoltanKochi AndrashShanrion MajyaDemarl DideZhenest OliveDejvidson Dzhejms Eduard PolMyurrej Dzhejms BrukShiposh SabolchPatsal AttilaBalint Balazh

(73)

Holder

Le Laboratuar ServeVernalis Limited

NOVEL HYDROXY-ESTER DERIVATIVES, A METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Russian patent published in 2020 - IPC C07D495/04 A61K31/519 A61K45/06 A61P35/00

Abstract RU 2734418 C2

FIELD: organic chemistry.

SUBSTANCE: present invention relates to a compound of formula (I)

where A is a group

in which 1 denotes a point of attachment to -NH- and 2 denotes a point of attachment to the phenyl ring. Values of radicals are given in the claim. Also disclosed is a method of producing compound (I), compound of formula (VI_A) and use thereof, compound of formula (VI_B), compound of formula (VII_B) and use thereof, pharmaceutical compositions which inhibit Mcl-1, use of the pharmaceutical composition, use of the compound of formula (I), (VII_A) or (VII_B), a combination inhibiting Mcl-1, using the combination, use of the compound of formula (I), (VII_A) or (VII_B).

EFFECT: disclosed are new compounds inhibiting Mcl-1 and possessing apoptotic properties, which enables their use for treating malignant growths and autoimmune diseases and immune system diseases.

36 cl, 22 ex, 1 tbl

Similar patents RU2734418C2

Title	Year	Author	Number
NOVEL AMINO ACID DERIVATIVES, A METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM	2016	Slavik Zoltan Sabo Zoltan Chekej Marton Patsal Attila Kochi Andrash Bryuno Alen Zhenest Olive Chen Itszen Dejvidson Dzhejms Eduard Pol Myurrej Dzhejms Bruk Ondi Levente Radich Gabor Shiposh Sabolch Prosenyak Agnesh Perron-Serra Fransuaz Balint Balazh	RU2747673C2
NOVEL AMMONIUM DERIVATIVES, A METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM	2016	Patsal Attila Slavik Zoltan Kochi Andrash Shanrion Majya Marano Ana Letisiya Zhenest Olive Demarle Dide Balint Balazh Shiposh Sabolch	RU2743098C2
NOVEL HYDROXY ACID DERIVATIVES, A METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM	2016	Slavik Zoltan Patsal Attila Balint Balazh Kochi Andrash Shanrion Majya Zhenest Olive Dejvidson Dzhejms Eduard Pol Myurrej Dzhejms Bruk Shiposh Sabolch Prosenyak Agnesh	RU2745430C1
NEW BICYCLIC DERIVATIVES, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM	2016	Balint Balazh Chekej Marton Sabo Zoltan Slavik Zoltan Kochi Andrash Shanrion Majya Zhenest Olive Chen Itszen Dejvidson Dzhejms Eduard Pol Myurrej Dzhejms Bruk Shiposh Sabolch Ondi Levente Prosenyak Agnesh	RU2760554C1
NOVEL THIENO-PYRIMIDINE DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM	2014	Kotchi Andrash Slavik Zoltan Sekej Marton Patsal Attila Sabo Zoltan Shiposh Sabolch Radich Gabor Proseniak Agnesh Balint Balazh Brjuno Alen Zheneste Olive Dejvidson Dzhejms Eduard Pol Marri Dzhejms Bruk Chen Itszen Perron-Serra Fransuaz	RU2605403C2
COMBINATION OF AN MCL-1 INHIBITOR AND A STANDARD DRUG FOR THE TREATMENT OF HEMATOLOGICAL MALIGNANCIES, ITS USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT	2018	Wei Andrew Moujalled Donia Pomilio Giovanna Geneste Olivier Maragno Ana-Leticia	RU2792057C2
COMBINATION OF MCL-1 INHIBITOR AND TAXANE COMPOUND, THEIR APPLICATIONS AND PHARMACEUTICAL COMPOSITIONS	2018	Porter Dejl Khalilovich Ensar Shanrion Majya Marano Ana Letisiya Zhenest Olive Merino Delfin Uittl Dzhejms Vajyan Fransua Visvejder Dzhejn Lindeman Dzheffri Lessen Gijom Marangoni Elizabetta	RU2763544C2
COMBINATION OF MCL-1 INHIBITOR AND MIDOSTAURIN, ITS APPLICATIONS AND PHARMACEUTICAL COMPOSITIONS	2019	Halilovic Ensar Wang Youzhen Morris Erick Konopleva Marina Skwarska Anna	RU2818453C2
COMBINATION OF BCL-2 INHIBITOR AND MCL-1 INHIBITOR, USE AND PHARMACEUTICAL COMPOSITIONS THEREOF	2017	Vej Endryu Mudzhalled Doniya Pomilio Dzhovanna Marano Ana Letisiya Zhenest Olive Klaperon Odri Maake Khajko Khalilovich Ensar Porter Dejl Morris Erik Van Yuchzhen Sangkhavi Snekha Mistri Prakash	RU2746705C2
NEW INDOLIZINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM	2013	Le-Digare Terri Kasara Patrik Stark Zherom-Benua Anlen Zhan-Mishel Dejvidson Dzhejms Eduard Pol Marri Dzhejms Bruk Grem Kristofer Dzhon Chen Itszen Zhenes Olive Khikman Dzhon Depil Stefan Le-Tiran Arno Niergesh Miklosh De-Nantej Gijom	RU2646223C2

RU 2 734 418 C2

Authors

Slavik Zoltan

Kochi Andrash

Shanrion Majya

Demarl Dide

Zhenest Olive

Dejvidson Dzhejms Eduard Pol

Myurrej Dzhejms Bruk

Shiposh Sabolch

Patsal Attila

Balint Balazh

Dates

2020-10-16—Published

2016-06-22—Filed