NOVEL AMMONIUM DERIVATIVES, A METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Russian patent published in 2021 - IPC C07D495/04 C07F9/6561 A61K31/519 A61K31/661 A61P35/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention refers to compounds of formula (I):

,

where: ♦ Y is -NH- group or an oxygen atom; ♦ R₁ is a linear or branched (C₁-C₆) alkyl group or a halogen atom; ♦ R₂, R₃ and R₄ independently represent a hydrogen atom, a halogen atom or a linear or branched (C₁-C₆) alkyl group; ♦ R₅ represents a hydrogen atom; ♦ R₆ represents or

♦ R₇ represents a hydrogen atom or a linear or branched (C₁-C₆)alkyl group; ♦ R₈ is -O-P(O)(O⁻)(O⁻) group, -OP(O)(O⁻)(OR₁₀) group, -OP(O)(OR₁₀)(OR₁₀') group, -O-SO₂-O- group, -O-SO₂-OR₁₀ group, dioxolyl, -O-C(O)-R₉ group, -O-C(O)-OR₉ group or -OC(O)-NR₉R₉' group; ♦ R₉ and R₉' independently of each other represent a hydrogen atom, a linear or branched (C₁-C₆)alkyl group or a linear or branched amino (C₁-C₆)alkyl group; ♦ R₁₀ and R₁₀' each independently represent a hydrogen atom, a linear or branched (C₁-C₆)alkyl group or an aryl (C₁-C₆) group, it is possible that thus defined ammonium existed in zwitterion form or had a monovalent anionic counterion, which are inhibitors of Mcl-1, as well as to pharmaceutical compositions containing said compound, and use thereof.

EFFECT: disclosed are new ammonium derivatives, a method for preparing them and pharmaceutical compositions containing them.

28 cl, 1 tbl, 32 ex