NOVEL AMINO ACID DERIVATIVES, A METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Russian patent published in 2021 - IPC C07D495/04 A61K31/519 A61P35/00 A61P37/00 

Abstract RU 2747673 C2

FIELD: organic chemistry.

SUBSTANCE: invention relates to a compound of formula (I):

where A is a group in which 1 denotes a point of attachment to -NH- and 2 denotes a point of attachment to the aromatic ring. Values of radicals are given in the claim. Also disclosed are methods of producing compound (I), pharmaceutical compositions inhibiting Mcl-1, and using compound (I) and a pharmaceutical composition.

EFFECT: novel compounds having pro-apoptotic properties are disclosed, which enables their use in pathologies involving apoptosis defect.

40 cl, 2 tbl, 279 ex

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RU 2 747 673 C2

Authors

Slavik Zoltan

Sabo Zoltan

Chekej Marton

Patsal Attila

Kochi Andrash

Bryuno Alen

Zhenest Olive

Chen Itszen

Dejvidson Dzhejms Eduard Pol

Myurrej Dzhejms Bruk

Ondi Levente

Radich Gabor

Shiposh Sabolch

Prosenyak Agnesh

Perron-Serra Fransuaz

Balint Balazh

Dates

2021-05-12Published

2016-06-22Filed