FIELD: organic chemistry.
SUBSTANCE: invention relates to a compound of formula (I):
where A is a group in which 1 denotes a point of attachment to -NH- and 2 denotes a point of attachment to the aromatic ring. Values of radicals are given in the claim. Also disclosed are methods of producing compound (I), pharmaceutical compositions inhibiting Mcl-1, and using compound (I) and a pharmaceutical composition.
EFFECT: novel compounds having pro-apoptotic properties are disclosed, which enables their use in pathologies involving apoptosis defect.
40 cl, 2 tbl, 279 ex
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Authors
Dates
2021-05-12—Published
2016-06-22—Filed