FIELD: medicine.
SUBSTANCE: invention relates to medicine. Disclosed is a method of treating type 2 diabetes mellitus, providing a glucose level reduction in a body, comprising administering to a subject a therapeutically effective amount of arylidene-2-oxindole of general formula (I)
where R1 is selected from H, nitro, halogen, C1-C4-alkoxy, NH(CO)C1-C4-alkyl, NH(CO)OC1-C4-alkyl, NH(CO)C5-C6-aryl, R2 is C5- C6-aryl or C5-C6-heteroaryl containing one or more groups used in combination with each other, selected from H, OH, nitro, halogen, C1-C4-alkoxy, where C5-C6-heteroaryl means 5–6-member aryl with 1 or 2 heteroatoms selected from group O, N, S.
EFFECT: invention provides more effective reduction of blood glucose concentration by simultaneously exposing GSK3 β and α-glucosidase, that is due to simultaneous action on two glucose concentration reduction mechanisms.
7 cl, 2 tbl, 25 ex, 2 dwg
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