FIELD: chemistry.
SUBSTANCE: group of inventions relates to amide-containing 2-oxindole derivatives of the general formula (I), where R1 is H, benzyl, C1-C4-alkyl, R2 is H, OH, OR6, R3 is COOH, CN, R4 is H, OC1-C4-alkyl, halogen, C1-C4-alkyl, COOC1-C4-alkyl, NHC(X)R7, R5 is C5-C6-aryl, C5-C6-heteroaryl, NHC1-C4-alkyl, NHC1-C4-haloalkyl, NHC3-C6-cycloalkyl, NHC5-C6-aryl, NHC5-C6-heteroaryl, OC5-C6-aryl, where C5-C6-heteroaryl contains 1 or 2 heteroatoms selected from O, N, S, R6 is C1-C4-alkyl, C(O)C1-C4-alkyl, R7 is C1-C4-alkyl, C1-C4-haloalkyl, OC1-C4-alkyl, C3-C6-cycloalkyl, C5-C6-aryl, C5-C6-heteroaryl, NHC1-C4-alkyl, NHC1-C4-haloalkyl, NHC3-C6-cycloalkyl, NHC5-C6-aryl, NHC5-C6-heteroaryl, OC5-C6-aryl, where C5-C6-heteroaryl contains 1 or 2 heteroatoms selected from O, N, S, X is O, S, to a method of obtaining these compounds and their use as medicines, as a component of the pharmaceutical composition for the treatment of ophthalmic diseases, as well as a method of treating ophthalmic diseases using a pharmaceutical composition based on compounds of formula (I).
.
EFFECT: use as pharmaceuticals, as a component of a pharmaceutical composition for the treatment of ophthalmic diseases, as well as a method of treating ophthalmic diseases using a pharmaceutical composition based on compounds of formula (I).
32 cl, 2 dwg, 29 ex, 2 tbl
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| METHOD OF PRODUCING 2-SUBSTITUTED 1-HYDROXY-1H-INDOLE-5,6-DICARBOXYLIC ACIDS | 2015 |
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| METHOD OF PRODUCING 2-SUBSTITUTED 1-HYDROXYPYRROLO[3,4-ƒ]INDOLE-5,7-(1H,6H)-DIONES | 2015 |
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