3-ACYLAMINOPYRIDIN DERIVATIVES, APPLICABLE AS SERINE-THREONINE PROTEINKINASE GSK3B INHIBITORS, AS MEDICATIONS FOR TYPE II DIABETES TREATMENT Russian patent published in 2015 - IPC C07D401/04 C07D401/14 C07D401/12 C07D405/12 C07D405/14 C07D413/12 C07D413/14 A61K31/4412 A61K31/444 A61P3/10 

Abstract RU 2570907 C2

FIELD: chemistry.

SUBSTANCE: invention relates to 3-acylaminopyridin-2(1H)-one and its novel derivatives, which can be potential medications for treatment of type II diabetes. , wherein X - -(CH2)n-n=0-2, -CH(OCH3)-, -CH=CH-; Y - 1-adamantyl, 4-isopropylphenyl,3-(methoxymethyl)-4-methoxyphenyl, 3-(4-methyl-1H-pyrazol-1-yl)methyl-4-methoxyphenyl, 4-(difluoromethoxy)phenyl, 3,5-dimethylisoxazol-4-yl, 3,5-dimethyl-4-nitro-1H-pyrazol-1-yl, 3-trifluoromethyl-1H-pyrazol-1-yl, 1-ethyl-3-trifluoromethyl-1H-pyrazol-5-yl, 1-benzyl-5-methyl-1H-1,2,3-triazol-4-yl; Z - 4 pyridyl, bromine.

EFFECT: obtaining medication for treating diabetes.

4 cl, 2 dwg, 3 tbl, 21 ex

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RU 2 570 907 C2

Authors

Alekseeva Marija Georgievna

Danilenko Valerij Nikolaevich

Zefirov Nikolaj Serafimovich

Mavletova Dilara Anvarovna

Morozov Aleksej Sergeevich

Osolodkin Dmitrij Ivanovich

Paljulin Vladimir Aleksandrovich

Dates

2015-12-20Published

2013-10-21Filed