USE OF SOLUBLE CD146 AS A BIOMARKER FOR SELECTION OF AN IN VITRO FERTILIZED EMBRYO FOR IMPLANTATION TO A MAMMAL Russian patent published in 2020 - IPC G01N33/68 

Abstract RU 2735542 C2

FIELD: medicine; embryology; immunology.

SUBSTANCE: group of inventions can be used to determine mammalian fertility. That is ensured by using CD146 (sCD146) soluble protein present in embryo culture medium as biomarker of implantation of said embryo in uterus of mammal. Group of inventions relates to a method of selecting an embryo produced by in vitro fertilization (IVF), for implantation into a uterus of a mammal, as well as to a method for increasing pregnancy probability in vitro in a mammal and a method of stimulating pregnancy in a mammal.

EFFECT: using the given group of inventions makes it possible to increase probability of pregnancy during fertilization in vitro in a mammal when determining threshold value of concentration sCD146 making 1164 pg per ml supernate of a medium for embryo cultivation.

13 cl, 6 dwg, 1 tbl

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RU 2 735 542 C2

Authors

Bardin Nathalie

Blot-Chabaud Marcel

Bouvier Sylvie

Lacroix Odile

Dignat-George Francoise

Gris Jean-Christophe Raymond

Dates

2020-11-03Published

2016-04-21Filed