COMBINED COATINGS BASED ON BIOLOGICALLY ACTIVE RGD-FUNCTIONALISED AMINOACID BISPHOSPHONATES AND PEO-SUBLAYER FOR TITANIUM Russian patent published in 2020 - IPC C07K7/06 A61L27/06 

FIELD: biotechnology.

SUBSTANCE: invention relates to production of combined coatings for titanium based on biologically active RGD-functionalised bisphosphonate derivatives Arg-Gly-Asp-Cys-(RGDC)-substituted ({[(2,5-dioxo-pyrrolidin-1-yl)alkanoyl]amino}-1-hydroxyalkane-1,1-diiyl)bisphosphonic acids and use of said compounds as organic coatings for simulating biological activity of PEO-modified surface of titanium implants. RGD-functionalised bisphosphonate derivatives of Arg-Gly-Asp-Cys-(RGDC)-substituted ({[(2,5-dioxo-pyrrolidin-1-yl)alkanoyl]amino}-1-hydroxyalkane-1,1-diiyl)bisphosphonic acids is applied by physical-chemical adsorption from aqueous solutions with concentration of ~10^-3 M/l for 1 hour on titanium (Grade 2) with inorganic oxidised porous sublayer, obtained during plasma-electrolytic oxidation.

EFFECT: technical result is obtaining coatings, improving adhesion and proliferation of mesenchymal stem cells, fibroblasts and osteoblastoid cells.

2 cl, 3 ex, 3 dwg