FIELD: chemistry.
SUBSTANCE: invention relates to use of fucidic acid amine derivatives of formula (1) - (4): (2Z)-2-[(3β,4α,8α,11α,14β,16β)-16-(acetyloxy)-11-hydroxy-4,8,10,14-tetramethyl-3-pyrrolidin-1-ylgonan-17-ylidene]-6-methylhept-5-enoic acid (1), (2Z)-2-[(3β,4α,8α,11α,14β,16β)-16-(acetyloxy)-3-(butylamino)-11-hydroxy-4,8,10,14-tetramethylgonane-17-ylidene]-6-methylhept-5-enoic acid (2), methyl (2Z)-2-[(3β,4α,8α,14β,16β)-16-(acetyloxy)-4,8,10,14-tetramethyl-11-oxo-3-pyrrolidin-1-ylgonan-17-ylidene]-6-methylhept-5-enoate (3) and methyl (2Z)-2-{(3β,4α,8α,11α,14β,16β)-16-(acetyloxy)-3-[(2-aminoethyl)amino]-11-hydroxy-4,8,10,14-tetramethylgonane-17-ylidene}-6-methylhept-5-enoate (4) as agents exhibiting high anti-tumour activity in vitro with respect to 4 leukaemia cell lines: HL-60, K-562, MOLT-4 and SR.
EFFECT: technical result: use of fucidic acid amine derivatives of formula (1)–(4), having high anti-tumour activity in vitro with respect to 4 leukaemia cell lines: HL-60, K-562, MOLT-4 and SR, inhibiting their growth from 70 % to complete death of cancer cells.
1 cl, 1 tbl, 3 ex
| Title |
Year |
Author |
Number |
| N,N'-BIS(3-AMINOPROPYL)BUTANE-1,4-DIAMINO DERIVATIVES OF FUSIDIC ACID, HAVING A WIDE SPECTRUM OF ANTIMICROBIAL ACTIVITY |
2019 |
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- Parfenova Lyudmila Vyacheslavovna
|
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| (2Z)-2-[(3Β, 4Α, 8Α, 11Α, 14Β, 16Β)-16-(ACETYLOXY)-3-({3-[(4-AMINOBUTYL)AMINO]PROPYL}AMINO)-11-HYDROXY-4,8,10,14-TETRAMETHYL GONANE-17-YLIDENE]-6-METHYLHEPT-5-ENOIC ACID WITH ANTIMICROBIAL AND FUNGICIDAL ACTIVITY AND METHOD FOR PRODUCTION THEREOF |
2019 |
- Salimova Elena Viktorovna
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- Parfenova Lyudmila Vyacheslavovna
|
RU2730604C1 |
| PROP-2-IN-1-IL-(2Z)-2-[(3-alpha, 4-alpha, 8-alpha, 11-alpha, 14-beta, 16-beta)-16-(ACETYLOXY)-3.11-DIHYDROXY-4,8,10,14-TETRAMETHYLGONANE-17-YLIDENE]-6-METHYLHEPT-5-ENOATE, PREPARATION METHOD AND ANTIMICROBIAL PROPERTIES |
2021 |
- Salimova Elena Viktorovna
- Savchenko Rimma Gafurovna
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|
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| (2Z)-2-[(4Α, 5Α, 8Α, 9Β, 13Α, 14Β, 16Β)-16-(ACETYLOXY)-3(Z),11(E)-BIS (HYDROXYIMINO)-4,8,10,14-TETRAMETHYLGONANE-17-YLIDENE]-6-METHYLHEPT-5-ENOIC ACID, METHOD OF PRODUCING AND ANTIMICROBIAL PROPERTIES |
2019 |
- Salimova Elena Viktorovna
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| (1-BENZYL-1H-1,2,3-TRIAZOL-4-YL)METHYL (Z)-2-((3S,4S,8S,10S,11R,14S,16S)-16-ACETOXY-3,11 -DIHYDROXY-4,8,10,14-TETRAMETHYLHEXADECAHYDRO-17H-CYCLOPENTA[a]PHENANTHRENE-17-YLIDENE)-6-METHYLHEPT-5-ENOATE EXHIBITING ANTIBACTERIAL AND FUNGICIDAL ACTIVITY |
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2023 |
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2008 |
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