FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to production of a fused protein of hyperglycosylated recombinant human coagulation factor IX (FIX), and can be used in medicine in therapy of haemorrhagic disease. Fused protein consists of serially from N-end to C-terminal, human coagulation factor IX, flexible peptide linker, at least one rigid fragment containing a carboxyl terminal peptide of the beta-subunit of human chorionic gonadotrophin and an immunoglobulin Fc-segment.
EFFECT: invention enables to obtain a fused FIX having high biological activity, an extended in vivo half-life and reduced immunogenicity.
16 cl, 2 tbl, 7 ex, 3 dwg
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