METHOD OF PRODUCING LUMINESCENT REGULARLY POLYFLUORENE MOLECULAR BRUSHES WITH SIDE CHAINS OF WATER-SOLUBLE HEAT-SENSITIVE BIOCOMPATIBLE POLYMERS Russian patent published in 2020 - IPC C08F257/00 

FIELD: chemistry.

SUBSTANCE: invention relates to chemistry of high-molecular compounds, specifically to a method of producing luminescent regularly grafted polyfluorene molecular brushes with side chains of water-soluble heat-sensitive biocompatible polymers by using a "grafting through" method for polycondensation, consisting in that polycondensation of fluorene macromonomer(s) (4–6 wt. %), including (them) side polymer chains of a future molecular brush of water-soluble heat-sensitive biocompatible polymers, which is 2,7-dibromofluorene with chains of polyalkyloxazoline or oligoethylene glycol attached to it in position 9,9, and second monomer (0.5–3 wt. %) - 2,7-pinacolone ester of diboronic acid-9,9-dihexyl-fluorene or 2,7-pinaclin dibonoic acid ester-9,9-dioctyl-fluorene, at ratio of macromonomer(s): second monomer = 1:1 in a solution of N,N-dimethylformamide in an atmosphere of an inert gas in the presence of catalyst - 1,1'-bis(diphenylphosphino)ferrocene palladium (II) chloride (0.25–0.35 wt. %), and 0.2M potassium carbonate solution (30–35 vol. %) in a microwave reactor at 95–100 °C and power 100 W for 1–1.5 hours, after completion of reaction solution is purified by fractional precipitation with subsequent centrifugation, purification is performed from residues of low-molecular and oligomeric impurities by dialysis for 2 days and centrifuging solution in test tube with membrane of porous regenerated cellulose, freezing solution and lyophilic drying for 2 days, obtaining hygroscopic preserved in exsicitor target product - luminescent molecular brush with link formula:

where p, k is molar fraction: p + k = 1, p = 0–1, k = 0–1; y = 3, 6; M_w = 120–380 kDa.

EFFECT: technical result: method of producing molecular brushes by "grafting through" method, characterized by high output of target product and high density of grafts.

1 cl, 12 ex, 4 dwg