Show metadata Hide metadata

(19)

(11)

2 736 501

(13)

(51)

IPC

C07D471/18(2006-01-01)

A61K31/407(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2018107941, 2016-08-05

(24)

Start date

2016-08-05

(22)

Actual filing date

2016-08-05

(45)

Published

2020-11-17

(72)

Inventor

Arner, Elias Set JenoStafford, William, ChesterCoussens, Nathan, PatrickLuci, Diane, KarenMaloney, David, JosephSimeonov, AntonJadhav, AjitDexheimer, Thomas, S.

(73)

Holder

Arner, Elias Set JenoThe United States Of America, As Represented By The Secretary, Department Of Health And Human Services

TRICYCLIC COMPOUNDS AND USE THEREOF FOR TREATING CANCER Russian patent published in 2020 - IPC C07D471/18 A61K31/407 A61P35/00

Abstract RU 2736501 C2

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to use of compounds of formula I, or pharmaceutically acceptable salts thereof, where X, Y, Z, R¹ and R² have values given in the claim, as a pharmaceutical agent acting by inhibiting cytosolic thioredoxin reductase, and which can be used for treating cancer diseases.

(I)

EFFECT: tricyclic compounds and use thereof for treating cancer are disclosed.

10 cl, 69 ex, 3 dwg

Similar patents RU2736501C2

Title	Year	Author	Number
PYRIDINES AND USE THEREOF IN TREATING CANCER	2016	Arner, Elias Set Jeno Stafford, William, Chester Coussens, Nathan, Patrick Luci, Diane, Karen Maloney, David, Joseph Simeonov, Anton Jadhav, Ajit Dexheimer, Thomas, S.	RU2730505C2
N- (PHENYLSULPHONYL) BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS	2017	Wang, Shaomeng Chen, Jianyong	RU2744358C2
N-(PHENYLSULFONYL)BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS	2017	Wang, Shaomeng Chen, Jianyong	RU2722560C1
MDM2 PROTEIN DESTRUCTORS	2017	Wang, Shaomeng Li, Yangbing Yang, Jiuling Aguilar, Angelo Zhou, Bing Hu, Jiantao Xu, Fuming Rej, Rohan Han, Xin	RU2743432C2
INHIBITOR COMPOUNDS	2013	Khelder Sven Blagg Dzhulian Solanki Savade Vuduard Khannakh Naud Sebasten Bavetsias Vassilios Sheldrejk Piter Innochenti Paolo Cheung Kvaj-Min Dz. Atrash Betras	RU2673079C2
PYRROLE AND PYRAZOLE DAAO INHIBITORS	2004	Fang K. Kevin Khopkins Set Kheffernan Mishel Chitil Majlan	RU2361862C2
SULPHONYLUREAS AND RELATED COMPOUNDS AND THEIR USE	2016	O'Neill Luke Coll Rebecca Cooper Matthew Robertson Avril Schroder Kate	RU2795512C2
VET PROTEIN DECOMPOSERS	2017	Wang, Shaomeng Zhou, Bing Xu, Fuming Hu, Jiantao Bai, Longchuan Yang, Chao-Yie	RU2752677C2
SPIRO OXINDOLE MDM2 ANTAGONISTS	2010	Van Shaomehn Juj Shankhaj Sun' Vehj Kumar Sandzheev Sun' Dusin' Tszou Pehn Chzhao Jujtszjun' Makichern Donna	RU2553269C2
IMPROVED HONOKIOL SYNTHESIS	2016	Jaracz, Stanislav Kozlowski, Marisa Eun Lee, Young Kim, Sun Min	RU2727202C2

RU 2 736 501 C2

Authors

Arner, Elias Set Jeno

Stafford, William, Chester

Coussens, Nathan, Patrick

Luci, Diane, Karen

Maloney, David, Joseph

Simeonov, Anton

Jadhav, Ajit

Dexheimer, Thomas, S.

Dates

2020-11-17—Published

2016-08-05—Filed