PYRROLE AND PYRAZOLE DAAO INHIBITORS Russian patent published in 2009 - IPC C07D231/54 C07D231/14 C07D231/16 C07D207/34 C07D209/44 C07D209/42 C07D491/04 A61K31/401 A61K31/403 A61K31/415 A61K31/416 A61P25/18 A61P25/28 

FIELD: chemistry.

SUBSTANCE: invention relates to new compounds with general formula (I) , where R¹ and R² are independently chosen from hydrogen, halogen, nitro, alkyl, alkylaryl and XYR⁵; X and Y are independently chosen from O and (CR⁶R⁷)_n; R³ represents hydrogen, alkyl or M; M represents an ion, chosen from aluminium, calcium, lithium, magnesium, potassium, sodium, zinc or their mixture; Z represents CR⁴; R⁴ is chosen from hydrogen, halogen, alkyl, alkylaryl and XYR⁵; R⁵ is chosen from aryl, substituted aryl, heteroaryl and substituted heteroaryl; R⁶ and R⁷ are independently chosen from hydrogen and alkyl; n is an integer from 1 to 6; at least one of R¹ and R² represents XYR⁵, and at least one of X and Y represents (CR⁶R⁷)_n. The invention also pertains to the method of increasing concentration of D-serine and/or reducing concentration of toxic products of D-serine oxidation under the effect of DAAO in mammals, involving introduction into a subject of a therapeutically effective amount of a formula I compound, to the method of treating schizophrenia, treating or preventing loss of memory and/or cognitive ability, to the method of improving learning ability, method of treating neuropathic pain, as well as to a pharmaceutical composition, with DAAO inhibitory activity, based on these compounds.

EFFECT: obtained are new compounds and a pharmaceutical composition based on these compounds.

27 cl, 4 tbl, 72 ex