FIELD: biotechnology.
SUBSTANCE: invention relates to the biological material inhibiting material and the blood purifier containing such material. Presented material contains a substrate, which has a functional layer with a polymer immobilized on the surface, which is in contact with the biological component. Polymer contains a link of a complex vinyl ester of saturated aliphatic monocarboxylic acid. Biological component contains thrombocytes and/or proteins. Polymer is copolymerised with a hydrophilic monomer, wherein the hydrophilic monomer is selected from a group, consisting of vinyl alcohol monomers, acryloyl morpholine monomers, vinylpyridine-based monomers, vinylimidazole-based monomers, vinylpyrrolidone monomers and vinylacetamide monomers. Number of carbon atoms in the aliphatic chain in the saturated aliphatic monocarboxylic acid ion signal, detectable in the analysis of the surface composition of the functional layer using the TOF-SIMS apparatus, ranges from 2 to 20. Peak, which characterizes presence of ester group, is present at XPS measurement of functional layer surface. Signal of saturated aliphatic monocarboxylic acid ion characterizes presence of copolymer, containing vinyl ester of saturated aliphatic monocarboxylic acid having antithrombogenicity.
EFFECT: technical result is obtaining of biological material component suppressing adhesion, which is able to suppress adhesion of thrombocytes and proteins, even when comes into contact with blood or the like.
11 cl, 2 tbl, 21 ex
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| HOLLOW FIBER MEMBRANE BLOOD PURIFIER | 2015 |
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