INHIBITING ADHESION OF BIOLOGICAL COMPONENT OF MATERIAL Russian patent published in 2020 - IPC A61M1/16 A61M1/18 A61L29/04 A61L31/04 B01D71/68 B01D63/02 B01D63/08 

Abstract RU 2738372 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to the biological material inhibiting material and the blood purifier containing such material. Presented material contains a substrate, which has a functional layer with a polymer immobilized on the surface, which is in contact with the biological component. Polymer contains a link of a complex vinyl ester of saturated aliphatic monocarboxylic acid. Biological component contains thrombocytes and/or proteins. Polymer is copolymerised with a hydrophilic monomer, wherein the hydrophilic monomer is selected from a group, consisting of vinyl alcohol monomers, acryloyl morpholine monomers, vinylpyridine-based monomers, vinylimidazole-based monomers, vinylpyrrolidone monomers and vinylacetamide monomers. Number of carbon atoms in the aliphatic chain in the saturated aliphatic monocarboxylic acid ion signal, detectable in the analysis of the surface composition of the functional layer using the TOF-SIMS apparatus, ranges from 2 to 20. Peak, which characterizes presence of ester group, is present at XPS measurement of functional layer surface. Signal of saturated aliphatic monocarboxylic acid ion characterizes presence of copolymer, containing vinyl ester of saturated aliphatic monocarboxylic acid having antithrombogenicity.

EFFECT: technical result is obtaining of biological material component suppressing adhesion, which is able to suppress adhesion of thrombocytes and proteins, even when comes into contact with blood or the like.

11 cl, 2 tbl, 21 ex

Similar patents RU2738372C2

Title Year Author Number
MEDICAL PURPOSE MATERIAL, MEDICAL PURPOSE SEPARATION MEMBRANE AND BLOOD PURIFICATION DEVICE 2017
  • Ushiro, Suguru
  • Hayashi, Akihiro
  • Ueno, Yoshiyuki
RU2748752C2
COPOLYMER AND MEDICAL DEVICE, SEPARATING MEMBRANE MODULE FOR MEDICAL USE AND BLOOD PURIFIER COMPRISING SAID COPOLYMER 2016
  • Ushiro Suguru
  • Takahashi Hiroshi
  • Ueno Yoshiyuki
RU2705399C2
SEPARATION MEMBRANE MODULE 2017
  • Ushiro, Suguru
  • Hayashi, Akihiro
  • Ueno, Yoshiyuki
RU2747972C2
COPOLYMER AND SEPARATION MEMBRANE, A MEDICAL DEVICE AND A BLOOD PURIFICATION APPARATUS USING SAID COPOLYMER 2017
  • Baba, Takeshi
  • Kawakami, Tomonori
  • Ushiro, Suguru
  • Ueno, Yoshiyuki
RU2735601C2
COPOLYMER AND MEDICAL MATERIAL CONTAINING IT 2017
  • Ushiro, Suguru
  • Hayashi, Akihiro
  • Ueno, Yoshiyuki
RU2757274C2
HOLLOW FIBER MEMBRANE MODULE AND METHOD FOR PRODUCING THEREOF 2015
  • Hayashi, Akihiro
  • Ueno, Yoshiyuki
RU2663747C2
ARTIFICIAL BLOOD VESSEL 2015
  • Fujita, Masaki
  • Kadowaki, Koji
  • Sakaguchi, Yuka
  • Tanahashi, Kazuhiro
  • Tsuchikura, Hiroshi
  • Yamada, Satoshi
RU2646506C1
HYDROPHILIC POLYMER COMPOUND POSSESSING ANTICOAGULATION EFFECT 2010
  • Sakaguti Khirokazu
  • Sakaguti Juka
  • Tanakhasi Kadzukhiro
RU2539566C2
HOLLOW FIBER MEMBRANE BLOOD PURIFIER 2015
  • Hata, Yosuke
  • Kawano, Chiharu
  • Hori, Ryoko
RU2682761C2
MEDICAL MATERIAL AND HOLLOW FIBRE MEMBRANE MODULE 2011
  • Ueno Josiyuki
  • Fudzita Masaki
  • Sugaya Khiroyuki
  • Khasimoto Kadzuyuki
  • Terasaka Khiroyuki
  • Koganemaru Rio
RU2596790C2

RU 2 738 372 C2

Authors

Ushiro, Suguru

Hayashi, Akihiro

Ueno, Yoshiyuki

Dates

2020-12-11Published

2017-07-28Filed