FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, in particular to a method for reducing clinical deterioration in a subject with Alzheimer's disease at an early stage, comprising administering a composition comprising a therapeutically effective amount of an antibody to protofibrils Ab to a subject, wherein the composition is administered in dose of 10 mg/kg of the Ab protofibril antibody in relation to the weight of the subject once every two weeks, and also wherein the subject is ApoE4-positive.
EFFECT: invention provides effective treatment of progression and/or prevention of Alzheimer's disease (AD).
25 cl, 82 dwg, 26 tbl, 5 ex
| Title |
Year |
Author |
Number |
| COMPOSITION CONTAINING ANTIBODY AGAINST ABETA PROTOFIBRILS AND INHIBITOR OF BETA-SECRETASE BACE1 FOR TREATMENT OF ALZHEIMER'S DISEASE |
2017 |
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|
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|
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|
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|
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|
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2008 |
- Mullan Majkl Dzh.
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|
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2007 |
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- Selin Dag
- Ehkkhol'M Pettersson Frida
- Ehnglund Khillevi
|
RU2429244C2 |
| MONOCLONAL BODY AGAINST AMYLOID BETA |
2008 |
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|
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2018 |
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- Teng, Edmond
|
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| MEMANTINE THERAPY FOR ALZHEIMER'S DISEASE OF LOW AND LOW TO MODERATE SEVERITY |
2005 |
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|
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