FIELD: chemistry.
SUBSTANCE: present invention relates to organic chemistry and specifically to a method of producing fendiline by reductive amination of 3,3-diphenylpropanal with 1-phenylethane-1-amine. Mixture of reactants is reacted in atmosphere of converter gas with volumetric content of carbon monoxide of more than 20% during catalysis with salt of metal of group VIII in polar solvent at high pressure and temperature.
EFFECT: what is presented is a new method of producing fendiline, which is simple, effective and suitable for use in industry.
6 cl, 1 tbl, 25 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR DIRECT AMINATION OF SECONDARY ALCOHOLS USING AMMONIA TO PRIMARY AMINES | 2011 |
|
RU2593994C2 |
| METHOD OF PREPARATION OF CARBONYL COMPOUND AND CARBOXYLIC ACID ESTERS | 2017 |
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| METHOD OF OBTAINING N-(4-BROMOPHENYL)-N-(2-ADAMANTYL)AMINE (BROMANTANE) | 2014 |
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| METHOD OF PRODUCING AMINES BY REDUCING AMINATION OF CARBONYL COMPOUNDS | 2022 |
|
RU2808453C1 |
| METHOD FOR OBTAINING SUBERANILIC ACID - PRECURSOR OF VORINOSTAT | 2023 |
|
RU2807017C1 |
| METHOD OF OBTAINING COMPLEXES OF 1-CHLORO-2-ALKYL (PHENYL) BORIRENES WITH SMe | 2016 |
|
RU2654806C2 |
| METHOD OF AMIDES OBTAINING FROM CARBONYL COMPOUNDS | 2016 |
|
RU2620269C1 |
| IMPROVED CHICHIBABIN'S METHOD FOR AMINATION OF PYRIDINE DERIVATIVES | 1995 |
|
RU2165414C2 |
| METHOD OF PRODUCING NON-RACEMIC 1- (ADAMANT-1-YL) -2- (2-NITRO-1-PLENYLETHYL) BUTANE-1,3-DIONE | 2015 |
|
RU2612966C1 |
| METHOD OF PRODUCING N-BENZYLIDENE BENZYLAMINE | 2012 |
|
RU2496770C2 |
