FIELD: chemistry.
SUBSTANCE: invention relates to method of producing non-racemic 1- (adamant-1-yl) -2- (2-nitro-1-phenylethyl) butane-1,3-dione of formula I . The method is carried out by enantioselective joining of 1- (adamant-1-yl) butan-1,3-dione to ω-nitrostyrene in the presence of a nickel complex of formula II in accordance with the following scheme (R = H). The method is characterized by the fact that 1,3-diketone containing adamantyl substituent is used as the Michael donor.
EFFECT: invention enables to simplify the process, reduce its price and obtain the product with good output.
2 ex
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Authors
Dates
2017-03-14—Published
2015-12-04—Filed