MULTIPLE OLIGONUCLEOTIDE FRAGMENTS ON A PEPTIDE CARRIER Russian patent published in 2020 - IPC C07K19/00 C12N15/113 A61K31/712 A61K47/64 

FIELD: biotechnology.

SUBSTANCE: invention relates to a conjugate suitable in medicine, selected from: Ac-(RXRRBR)₂XFKE(PMO)G(PMO), Ac-(RXRRBR)₂XFD(d-Glu)(PMO)E(PMO)G(PMO), Ac-E(PMO)(RXRRBR)₂XFKG(PMO), Ac-E(PMO)(RXRRBR)₂XFKE(PMO)G(PMO), Ac-E(PMO)(RXRRBR)₂XFK(d-Glu)(PMO)E(PMO)G(PMO), Ac-(d-Glu)(PMO)E(PMO)(RXRRBR)₂XFKG, Ac-(dGlu)(PMO)E(PMO)(RXRRBR)₂XFKG(PMO), Ac-(RXRRBR)₂XE(PMO)G(PMO), Ac-(d-Glu)(PMO)E(PMO)(RXRRBR)₂XFKE(PMO)G(PMO), Ac-(d-Glu)(PMO)E(PMO)(RXRRBR)₂XFK(d-Glu)(PMO)E(PMO)G(PMO) and Ac-(RXRRBR)₂XE(PMO)G(PMO), Ac-(RXRRBR)₂XFKE(PMO)G(PMO), Ac-E(PMO)(RXRRBR)₂XFKE(PMO)G(PMO), where Ac is acetyl, R is D-arginine, X is 6-aminohexanoic acid, B is β-alanine, E—glutamic acid, G—glycine, d-Glu—D-glutamic acid, D—aspartic acid, K—lysine, F—phenylalanine, PMO is oligonucleotide of 15–30 subunits of formula: ,

where B is selected from C, G, A or T, the PMO sequence is selected from SEQ ID NO: 85.

EFFECT: novel conjugates effective for modulating gene expression.

7 cl, 3 dwg, 4 tbl, 1 ex