LIPOSOMAL COMPOSITIONS AND SOLID PERORAL MEDICINAL FORMS COMPRISING SUCH COMPOSITIONS Russian patent published in 2021 - IPC A61K9/127 A61K9/28 A61K9/42 A61K9/48 A61K38/12 A61K47/44 C07K7/64 

FIELD: pharmaceuticals.

SUBSTANCE: invention can be used in pharmaceuticals and relates to a solid peroral medicinal form containing liposomes including a conjugate of at least one type of a cell penetrating peptide (CPP) and a compound selected from a lipid and fatty acid. Said conjugate is part of a double lipid layer of the liposome. The CPP part of the conjugate is present on the surface of the liposome, and the CPP is selected from the group consisting of linear or cyclised penetratin (SEQ ID NO:1; RQIKIWFQNRRMKWKK), linear or cyclised TAT (transcription transactivator)-peptide (SEQ ID NO:2; CGRKRKKPRQRRRPPQC), linear or cyclised R9 (SEQ ID NO:4; RRRRRRRRR) or cyclised CPP containing at least 50% lysine and/or arginine fragments. The medicinal form constitutes a gastroresistant solid peroral medicinal form additionally including at least one peptide medicinal product, protein or antibody in solid peroral medicinal form. The invention also relates to a use of the solid peroral medicinal form for peroral delivery of a peptide medicinal product, protein or antibody.

EFFECT: technical result consists in creation of solid dosed medicinal forms providing improved bioavailability during peroral administration of macromolecular medicinal products.

11 cl, 1 tbl, 19 dwg, 9 ex