THERAPEUTIC AGENTS FOR REDUCTION OF PARATHYROID HORMONE LEVELS Russian patent published in 2015 - IPC C07K7/06 A61K38/08 A61P3/14 A61P5/20 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to compounds, possessing activity, which reduces levels of a parathyroid hormone. The compound contains a peptide and a conjugating group, where the peptide has an amino acid sequence of formula: X₁-X₂-X₃-X₄-X₅-X₆ ^_X₇, in which X₁ is D-cysteine; X₂ represents an amino acid, selected from a group, consisting of D-arginine and non-cationic amino acid; X₃ represents D-arginine; X₄ represents an amino acid, selected from a group, consisting of D-arginine and a non-cationic amino acid; X₅ represents D-arginine; X₆ represents a non-cationic amino acid; X₇ represents D-arginine; and where the peptide is bound with the conjugating group by means of a disulphide bond. The compounds can be applied for treating subjects, suffering from, for instance, primary, secondary or tertiary hyperparathyroidism, hypocalcaemia, malignant tumour, metastatic disease of the bone or osteoporosis.

EFFECT: obtaining the compounds which possess the activity, reducing parathyroid hormone levels.

60 cl, 14 dwg, 11 tbl, 11 ex