FIELD: biotechnology.
SUBSTANCE: invention relates to fused proteins with anti-tumor activity, and can be used in medicine for anticancer therapy. Fusion polypeptide contains an antibody or a fragment thereof binding to a tumor-specific antigen selected from mesothelin, PD-L1 (programmed death ligand 1), Her2 (EGFR-related human protein 2), CD19, MUC1, EGFR and VEGFR; linker and protein inducing natural killers (NK) from CXCL16. Fused peptide can be obtained by a recombinant method. Also disclosed are pharmaceutical compositions containing said fused peptide, and a method of treating cancer.
EFFECT: invention provides an anti-cancer effect ensured by induction of NK cell migration.
12 cl, 32 dwg, 4 tbl, 10 ex
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