FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, specifically to the production of a cytolytic immune effector cell for the adoptive cell transfer; it can be used in medicine. The produced cell co-expresses the first chimeric antigen receptor (hereinafter – CAR) binding to CD19 and the second CAR binding to CD22 on the cell surface; it can be used for the effective therapy of malignant tumor that is characterized in the presence of cells that express CD19 and/or CD22.
EFFECT: obtaining a cell for the therapy of malignant tumors.
19 cl, 14 dwg, 7 tbl, 4 ex
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Authors
Dates
2022-03-23—Published
2015-12-23—Filed