FIELD: biotechnology.
SUBSTANCE: antibody to ICAM-1 or its antigen-binding fragment are proposed. Nucleic acid molecules encoding the specified antibody, a recombinant expression vector, and a recombinant cell for the production of an antibody according to the invention are also proposed. In addition, a pharmaceutical composition for the prevention or treatment of a disease mediated with immune cells, as well as a composition for detection of ICAM-1 are provided. Compositions contain an antibody to ICAM-1 or its antigen-binding fragment as an active ingredient.
EFFECT: invention provides regulation of differentiation and function of dendritic cells for more efficient control of an immune response.
14 cl, 39 dwg, 11 tbl, 6 ex
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