FIELD: biotechnology.
SUBSTANCE: invention relates to modified fibroblast growth factor 1 (FGF-1) polypeptides, and can be used in medicine for the treatment or prevention of a corneal disease, disorder or condition in a mammal, including herpetic keratopathy, neurotrophic keratopathy, corneal endothelial dystrophy or damage caused by a chemical or blister. The following is proposed: a recombinant modified FGF-1 polypeptide containing mutations in the wild-type FGF-1 sequence, namely the polypeptide contains three substitutions Cys16Ser, Ala66Cys and Cys117Val and methionine attached to the N-terminus of the following SEQ ID NO: 1.
EFFECT: invention provides the production of an FGF-1 polypeptide with an increased ability to induce cell proliferation compared to wild-type FGF-1 presented in the following SEQ ID NO: 1.
13 cl, 12 dwg, 16 ex
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