FIELD: biochemistry.
SUBSTANCE: invention relates to the single-domain sdAb antibody to arachidonate-12-lipoxygenase ALOX12 capable of specifically binding with ALOX12 antigen. Also disclosed is use of said antibody for treating a disease mediated by ALOX12, for preventing the development of a disease mediated by ALOX12, as well as to prevent recurrence of disease mediated by ALOX12. Invention also relates to an isolated polypeptide capable of specifically binding to ALOX12 antigen.
EFFECT: invention enables effective treatment of ALOX12 mediated disease in a subject.
17 cl, 10 dwg, 4 tbl, 5 ex
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Authors
Dates
2021-02-04—Published
2016-11-02—Filed