SINGLE-DOMAIN ANTIBODIES DIRECTED AGAINST INTRACELLULAR ANTIGENS Russian patent published in 2021 - IPC C07K16/10 C07K16/40 A61K39/42 A61P31/12 

Abstract RU 2742248 C2

FIELD: biochemistry.

SUBSTANCE: invention relates to the single-domain sdAb antibody to arachidonate-12-lipoxygenase ALOX12 capable of specifically binding with ALOX12 antigen. Also disclosed is use of said antibody for treating a disease mediated by ALOX12, for preventing the development of a disease mediated by ALOX12, as well as to prevent recurrence of disease mediated by ALOX12. Invention also relates to an isolated polypeptide capable of specifically binding to ALOX12 antigen.

EFFECT: invention enables effective treatment of ALOX12 mediated disease in a subject.

17 cl, 10 dwg, 4 tbl, 5 ex

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RU 2 742 248 C2

Authors

Singh, Sunanda

Dates

2021-02-04Published

2016-11-02Filed