FIELD: biochemistry.
SUBSTANCE: invention relates to the single-domain sdAb antibody to arachidonate-12-lipoxygenase ALOX12 capable of specifically binding with ALOX12 antigen. Also disclosed is use of said antibody for treating a disease mediated by ALOX12, for preventing the development of a disease mediated by ALOX12, as well as to prevent recurrence of disease mediated by ALOX12. Invention also relates to an isolated polypeptide capable of specifically binding to ALOX12 antigen.
EFFECT: invention enables effective treatment of ALOX12 mediated disease in a subject.
17 cl, 10 dwg, 4 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SINGLE-DOMAIN ANTIBODIES DIRECTED AGAINST INTRACELLULAR ANTIGENS | 2016 |
|
RU2741110C2 |
| SINGLE-DOMAIN ANTIBODIES DIRECTED AGAINST INTRACELLULAR ANTIGENS | 2016 |
|
RU2742247C2 |
| SINGLE-DOMAIN ANTIBODIES AGAINST INTRACELLULAR ANTIGENS | 2015 |
|
RU2810002C2 |
| MONOCLONAL ANTIBODY, BINDING WITH EBOLA VIRUS GLYCOPROTEIN, DNA FRAGMENTS CODING THIS ANTIBODY, AND ANTIGEN-BINDING FRAGMENT | 2015 |
|
RU2630304C2 |
| MONOCLONAL ANTIBODY, BINDING WITH EBOLA VIRUS GLYCOPROTEIN, DNA FRAGMENTS CODING THIS ANTIBODY, AND ANTIGEN-BINDING FRAGMENT | 2015 |
|
RU2639533C2 |
| MONOCLONAL ANTIBODY, LINKING WITH E-BIR VIRUS GLOBE-PROTEIN, DNA FRAGMENTS CODING THIS ANTIBODY AND ANTIGEN-BINDING FRAGMENT | 2016 |
|
RU2644334C2 |
| VACCINE AGAINST HIV/AIDS | 2010 |
|
RU2475264C2 |
| SINGLE-DOMAIN ANTIBODY AND DERIVATIVES THEREOF TO LIGAND-1 PROTEIN OF PROGRAMMED CELL DEATH (PDLI) | 2016 |
|
RU2715595C2 |
| BISPECIFIC ANTI-HER2 / ANTI-HER3 ANTIBODIES | 2016 |
|
RU2653443C2 |
| CANCER TREATMENT WITH CHIMERIC CD33 ANTIGEN RECEPTOR | 2015 |
|
RU2747384C2 |
