NOVEL PIPERIDINYL DERIVATIVES, A METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Russian patent published in 2021 - IPC C07D487/04 C07D495/04 A61K31/519 A61P35/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I)

,

where: ♦ R₁ is a phenyl group, ♦ R₂ is a hydrogen atom, ♦ R₃ represents a hydrogen atom, a methyl group, -CH₂-CH(CH₃)₂ group, -CH₂-CF₃ group, -C(O)-CH₃ group, -C(O)-CH(CH₃)₂ group, -C(C-)-C(CH₃)₃ group, -C(O)-CH₂-C(CH₃)₃ group, or -C(C-)-OC(CH₃)₃ group, ♦ n is an integer equal to 0, 1 or 2, ♦ W is a group

■ is

or ■ X is a carbon atom or a nitrogen atom, ■ R₄ represents a hydrogen atom, a halogen atom, a linear or branched (C₁-C₆)alkyl group, a linear or branched (C₂-C₆)alkenyl group, a linear or branched (C₂-C₆)alkynyl group, -Y₁-NR₆R₇ group, -Y₁-OR₆ group, a linear or branched halogen (C₁-C₆) alkyl group, an oxo group, -Y₁-Cy₁ group, -Cy₁-R₇ group, -Cy₁-OR₇ group or -Y₁-NR₆-C(O)-R₇ group, ■ R₅ represents a hydrogen atom, a halogen atom, a linear or branched (C₁-C₆)alkyl group, a piano group, or a hydroxy (C₁-C₆)alkyl group, ■ R₆ represents a hydrogen atom, or a linear or branched (C₁-C₆)alkyl group, or -Y₂-Si[(C₁-C₄)alkyl]₃ group, ■ R₇ is a hydrogen atom, a linear or branched (C₁-C₆)alkyl group or -Y₂-Cy₂ group, ■ Y₁ and Y₂ independently represent a bond or a linear or branched (C₁-C₄) alkylene group, ■ R₈ represents a hydrogen atom or a linear or branched (C₁-C₆)alkyl group (other radical values are given in claim 1), which inhibits activity of USP7 protein, as well as containing pharmaceutical compositions and combinations thereof.

EFFECT: disclosed are novel piperidinyl derivatives, a method for preparing them and pharmaceutical compositions containing them.

23 cl, 1 tbl, 198 ex