FIELD: pharmaceuticals.
SUBSTANCE: group of inventions relates to a pharmaceutical composition and use thereof for treating gastrointestinal cancer, lung cancer and breast cancer, as well as a pharmaceutical composition preparation method. Composition comprises (R,E)-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)propenamide or its pharmacologically acceptable salt, cross-linked polyvinylpyrrolidone, lactose and microcrystalline cellulose as filler, polyvinylpyrrolidone as binder, magnesium stearate as lubricant in certain amounts. Method of preparing a pharmaceutical composition comprises a step of mixing (R,E)-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)propene-amide or its pharmacologically acceptable salt and cross-linked polyvinylpyrrolidone.
EFFECT: group of inventions provides a fast dissolving pharmaceutical composition for treating cancer.
6 cl, 9 dwg, 3 tbl, 17 ex
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