FIELD: pharmaceuticals.
SUBSTANCE: present invention provides a method for preparing a pharmaceutical composition containing a quinoline derivative or a salt thereof. More specifically, the present invention provides a method of producing a pharmaceutical composition, containing (R,E)-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)-propenamide or its pharmaceutically acceptable salt. This method involves application of a wetting agent containing at least one organic solvent for wet granulation during preparation of the pharmaceutical composition.
EFFECT: pharmaceutical composition obtained by this method has uniform particle size distribution during the method of obtaining and characteristics of fast and uniform dissolution.
12 cl, 2 tbl, 11 ex, 8 dwg
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