CRYSTALLINE FORM I OF TYROSINE KINASE INHIBITOR DICALETAT AND METHOD FOR ITS PREPARATION Russian patent published in 2017 - IPC C07D401/14 A61K31/4709 A61P35/00

Abstract RU 2631321 C2

FIELD: pharmacology.

SUBSTANCE: invention relates to the crystalline form I of (R,E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)acrylamide dimaleate, a method for its preparation, a pharmaceutical composition based thereon, and its use.

EFFECT: resulting crystalline form I of dimaleate has good crystal stability and chemical stability and can be used to prepare drugs for treatment of diseases associated with EGFR tyrosine protein kinase or HER-2 receptor tyrosine protein kinase.

7 cl, 4 dwg, 2 tbl, 7 ex

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RU 2 631 321 C2

Authors

Sun Pyaoyan

U Guajli

Yuan Bo

Chen Yuntszyan

Dates

2017-09-21—Published

2013-06-04—Filed