FIELD: pharmaceuticals.
SUBSTANCE: invention relates to the field of pharmaceuticals, namely, to inactivating human cultural rotavirus method. The method consists in the fact that the suspension of human rotavirus, obtained by successive passages on the culture of transplanted animal cells Cell Growth&Differentiation (CG&D), is subjected to freezing-thawing, centrifuged, then the resulting supernatant virus containing liquid is exposed to UV-C radiation with a wavelength of 253.7 nm, reaching a damaging biological dose of 178 J/m2.
EFFECT: invention provides 100% inactivation of rotavirus infectious properties, while maintaining its protein structure and immunogenic properties.
1 cl, 4 tbl, 3 ex, 2 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF HUMAN CULTURE ROTAVIRUS INACTIVATION | 2019 |
|
RU2738404C1 |
| SORBED INACTIVATED VACCINE AGAINST CATTLE ROTAVIRAL INFECTION | 2005 |
|
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|
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| TRANSMISSIBLE GASTROENTERITIS OF SWINE VIRUS STRAIN FOR PRODUCTION OF DIAGNOSIS AND VACCINE PREPARATIONS | 2004 |
|
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| TRANSMISSIBLE GASTROENTERITIS OF SWINE VIRUS STRAIN FOR PRODUCTION OF DIAGNOSIS AND VACCINE PREPARATIONS | 2004 |
|
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| TRANSMISSIBLE GASTROENTERITIS OF SWINE VIRUS STRAIN FOR PRODUCTION OF DIAGNOSIS AND VACCINE PREPARATIONS | 2004 |
|
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| METHOD OF HUMAN ROTAVIRUS ADAPTATION TO GROWTH ON TRANSPLANTATED ANIMAL CELL CULTURES | 2018 |
|
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| MIXED VACCINE AGAINST ROTA-, CORONAVIRAL AND ESCHERICHIA DIARRHEA IN NEWBORN PIGLETS | 1998 |
|
RU2137499C1 |
