CRYSTAL FORMS 5-CHLORO-N2 - (2-ISOPROPOXY-5-METHYL-4-PIPERIDINE-4-YL-PHENYL) - N 4 - [2-(PROPANE-2-SULFONYL)- PHENYL] - PYRIMIDINE-2,4-DIAMINE Russian patent published in 2021 - IPC C07D401/12 

FIELD: chemistry.

SUBSTANCE: invention relates to a method for producing 5-chloro-N2- (2-isopropoxy-5-methyl-4-piperidin-4-yl-phenyl) -N4- [2- (propane-2-sulfonyl) -phenyl] -pyrimidine-2 , 4-diamine dihydrochloride, which involves mixing 2-isopropoxy-5-methyl-4- (piperidin-4-yl) aniline dihydrochloride and 2,5-dichloro-N- (2- (isopropylsulfonyl) phenyl) -pyrimidine-4- amine in 2-propanol. The invention also relates to a method for producing 5-chloro-N2- (2-isopropoxy-5-methyl-4-piperidin-4-ylphenyl) -N4- [2- (propane-2-sulfonyl) phenyl] pyrimidine-2,4- diamine, which is based on the method mentioned above, and further comprises the step of adding an aqueous solution of NaOH.

EFFECT: method has been developed for obtaining 5-chloro-N2- (2-isopropoxy-5-methyl-4-piperidin-4-yl-phenyl) -N4- [2- (propane-2-sulfonyl) -phenyl] -pyrimidine- 2,4-diamine dihydrochloride, which makes it possible to get a product with a high yield and purity.

6 cl, 6 dwg, 2 tbl, 4 ex