FIELD: chemistry.
SUBSTANCE: invention relates to a method for synthesis of 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-[2-(propane-2-sulphonyl)-phenyl]-pyrimidin-2,4-diamine (ceritinib) and/or intermediates thereof, to use thereof as pharmaceutical agents and pharmaceutical compositions and to use of intermediates for producing cerithinib.
EFFECT: disclosed is a chemical method of producing pyrimidine derivatives and intermediate compounds thereof.
15 cl
| Title | Year | Author | Number |
|---|---|---|---|
| THIOPHENE CARBOXAMIDE DERIVATIVE AND AGENT FOR CONTROLLING A PLANT DISEASE, CONTAINING SAID DERIVATIVE | 2019 |
|
RU2776177C1 |
| HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, METHOD OF ANTAGONISM OF ANGIOTENSIN-II | 1992 |
|
RU2168510C2 |
| PROCESSES FOR PREPARING DIHYDROPYRIMIDINE DERIVATIVES AND INTERMEDIATE PRODUCTS THEREOF | 2014 |
|
RU2697707C1 |
| METHOD OF PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE THROUGH COUPLING USING TRANSITION METAL AS CATALYST | 2010 |
|
RU2510393C9 |
| METHOD FOR PREPARING SULFONYLCARBAMATE BILE ACID DERIVATIVES | 2018 |
|
RU2791682C2 |
| METHOD AND INTERMEDIATE COMPOUNDS FOR PRODUCING 5-BIPHENYL-4-IL-2-METHYLPENTANIC ACID DERIVATIVES | 2013 |
|
RU2636936C2 |
| METHOD OF PRODUCING [(3-HYDROXYPYRIDINE-2-CARBONYL)AMINO]ALKANOIC ACIDS, ESTERS AND AMIDES | 2012 |
|
RU2602083C2 |
| METHOD FOR PRODUCING [(3-HYDROXYPYRIDINE-2-CARBONYL)AMINO]ALKANE ACIDS, ESTERS AND AMIDES | 2012 |
|
RU2764667C2 |
| NEW METHOD AND NEW INTERMEDIATE COMPOUNDS | 2016 |
|
RU2769445C2 |
| NOVEL METHOD FOR OBTAINING INTERMEDIATE COMPOUNDS, APPLIED IN OBTAINING NEP INHIBITORS | 2011 |
|
RU2573824C2 |
