CHIMERIC ANTIBODIES FOR TREATMENT OF DISEASES CHARACTERIZED BY AMYLOIDE DEPOSITION Russian patent published in 2021 - IPC A61K39/395 A61P3/00 C07K14/435 C07K16/46 C12N15/13 C12N15/63 

FIELD: medicine/pharmaceuticals.

SUBSTANCE: group of inventions relates to the field of medicine and pharmaceuticals. 1-3 objects are a chimeric mouse and human antibody that binds to amyloid fibrils and contains the V_K regions of SEQ ID NO: 47 and V_H of SEQ ID NO: 48, and a pharmaceutical composition containing the antibody used for the treatment of primary amyloidosis. Objects 4-7 represent a method for producing a chimeric antibody and vector constructs 11-1F4VHpG1D200, 11-1F4VK.pKN100 and pG1KD200-11-1F4 used in the preparation. 8, the object is the use of an antibody having a label attached thereto to detect the presence of amyloid deposits. 9-11 objects are chimeric murine and human antibodies produced by the methods of the invention. Objects 12 and 13 are polypeptides that are antibody regions V_K of SEQ ID NO: 47 and V_H of SEQ ID NO: 48. Objects 14 and 15 are polynucleotides of SEQ ID NO: 42 and SEQ ID NO: 45 encoding these polypeptides.

EFFECT: technical result consists in treating primary amyloidosis and detecting the presence of amyloid deposits using the antibodies according to the invention.

22 cl, 6 tbl, 6 ex, 8 dwg