FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to an antibody against L1CAM or its antigen-binding fragment. The invention also relates to a chimeric antigen receptor containing the specified antibody, a nucleic acid encoding it, an expression vector and an effector cell expressing a polypeptide of the chimeric antigen receptor. The effector cell is a T-lymphocyte. In addition, the use of antibodies and effector cells expressing the chimeric antigen receptor for the treatment or prevention of cancer and inflammatory diseases has been proposed.
EFFECT: antibody against L1CAM or an antigen-binding fragment according to the present invention is excellent in specificity and affinity for L1CAM and, thus, can be used in the treatment and diagnosis of cancers associated with high expression of L1CAM and diseases associated with inflammatory disorders.
29 cl, 109 dwg, 19 tbl, 6 ex
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