METHOD FOR DETERMINING THE PROBABILITY OF AN UNFAVOURABLE OUTCOME IN A TUBERCULOSIS PATIENT WITH HIV INFECTION IN A MEDICAL INSTITUTION OF THE FEDERAL PENITENTIARY SERVICE OF THE RUSSIAN FEDERATION ON THE BASIS OF ONE LABORATORY AND FOUR CLINICAL SIGNS Russian patent published in 2021 - IPC A61B5/00 

Abstract RU 2746528 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to infectious diseases and phthisiology. A detailed clinical examination is carried out. The presence or absence of the following clinical manifestations is clarified: complaints of shortness of breath, weight loss, fever, the presence of splenomegaly. It’s also necessary to count stab neutrophils in the general blood test. Then the following calculation is carried out in accordance with the following formula: z=(-5.34338)+1.30818×(SOB)+1.83543×(WL)+1.82002×(S)+1.90303×(F)+(-0.011090)×(P1) where “SOB” is shortness of breath, “WL” is weight loss, “S” is splenomegaly, “F” – fever, “P1” is the percentage of stab neutrophils in the general blood test. The sum (z) of the numerical values ​​of the signs is calculated. The values are multiplied by the discriminant coefficient of the signs: 1.30818 for shortness of breath, 1.83543 for weight loss, 1.82002 for splenomegaly, 1.90303 for fever, (-0.011090) for the numerical value of the percentage of stab neutrophils in the general blood test. After that the values are summed with a constant equal to (-5. 34338) followed by calculation using the original formula. The probability of an unfavorable outcome in a tuberculosis patient with HIV infection upon admission to the hospital of the Federal Penitentiary Service of the Russian Federation is calculated using the formula. If a probability value is 50% or higher, the risk of an unfavorable outcome and the need for hospitalization of the patient to the intensive care unit are predicted; if the probability value is below 50%, the patient is admitted to the hospital ward.

EFFECT: method makes it possible to determine the probability of an unfavorable outcome in a tuberculosis patient with HIV infection in a medical institution of the Federal Penitentiary Service of the Russian Federation (FSIN) by a limited number of clinical signs and one laboratory sign, which, individually and in combination, have high sensitivity and specificity.

1 cl, 2 ex, 2 tbl, 1 dwg

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RU 2 746 528 C1

Authors

Borovitskij Vladislav Semenovich

Razin Maksim Petrovich

Dates

2021-04-15Published

2020-09-21Filed