AMINOPYRIDINE DERIVATIVES AND THEIR USE AS SELECTIVE ALK-2 INHIBITORS Russian patent published in 2021 - IPC C07D401/10 C07D401/12 C07D401/14 C07D405/14 C07D409/14 C07D411/14 C07D413/10 A61K31/4427 A61P19/00 

FIELD: pharmacology.

SUBSTANCE: invention relates to a compound of Formula (I) in free form or in the form of a pharmacologically acceptable salt

(I),

wherein L represents a relationship, (CH₂)_n, –CH(CH₃)–, –O–(CH₂)_n–, –C(O)–, –C(O)–NH–(CH₂)_n–; n equals 1, 2 or 3; R₁ is C₃–C₇cycloalkyl, optionally substituted once or more than once by a substituent independently selected from hydroxyl, halogen, C₁–C₃alkyl; or bridged C₅–C₁₀cycloalkyl, optionally substituted once or more than once by a substituent independently selected from hydroxyl and hydroxyC₁–C₃alkyl; R₂ and R₃ are independently selected from H, halogen and C₁–C₃alkyl; R₄ is an N-containing heterocyclic non-aromatic ring, optionally containing one or more additional heteroatoms selected from N, O or S, where the specified ring is optionally substituted once or more than once by R₇; each R₇ is independently selected from C₁–C₃alkyl, hydroxyC₁–C₃alkyl, halogenC₁–C₃alkyl, C₁–C₃alkoxyC₁–C₃alkyl, halogenC₁–C₃alkoxyC₁–C₃alkyl, C₂–C₄alkynyl, cyanoC₁–C₃alkyl and (CH₂)_m–R₈; m equals 0, 1, 2 or 3; R₈ is selected from: 4–, 5– or 6-membered saturated or unsaturated non-aromatic heterocyclic ring containing one or more heteroatoms selected from N, O, or S, with the specified ring not necessarily replaced once or more than once by a substitute, independently selected from oxo SO₂C₁–C₃alkyl and halogenC₁–C₃alkyl; or C₃–C₆cycloalkyl, optionally substituted once or more than once by halogen, which is used to suppress the activity of ALK–2 receptor; as well as to pharmaceutical compositions containing this compound, and the use of this compound in the treatment of heterotopic ossification and progressive ossifying fibrodysplasia.

EFFECT: this invention can be used in the treatment of heterotopic ossification and progressive ossifying fibrodysplasia.

18 cl, 19 dwg, 12 tbl, 93 ex