MULTIVALENT AND MULTISPECIFIC HYBRID PROTEINS THAT BIND TO DR5 Russian patent published in 2021 - IPC C07K16/30 C07K19/00 C12N15/09 A61K39/00 A61P35/00 

Abstract RU 2748620 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology, specifically to the preparation of a polypeptide binding to death receptor 5 (DR5), and can be used in medicine.

EFFECT: resulting polypeptide contains many DR5-binding domains (DR5BD) representing VHH and can be used in effective cancer therapy or to reduce the number of regulatory T cells.

41 cl, 9 dwg, 4 ex

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RU 2 748 620 C2

Authors

Timmer Dzhon K.

Dzhons Kajl S.

Razai Amir S.

Khussejn Abrakhim

Villis Ketlin M.

Devero Kuinn

Ekelman Brendan P.

Dates

2021-05-28Published

2016-07-18Filed