FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, namely to hybrid proteins based on protein-1 of programmed cell death (hereinafter – PD-1); it can be used in medicine for the treatment, reduction, or prevention of metastasis or invasion of tumor in an object with cancer and for the treatment of an object with an infection. Hybrid protein of sPD-1-Fc protein is proposed, containing a domain of a variant of soluble PD-1 (hereinafter – sPD-1), including an amino acid substitute compared to SEQ ID NO: 1, where the specified amino acid substitute is in a position selected from a group consisting of 120, 112, 107, 104, 67, 69, 96, and 42; and where the specified domain of sPD-1 variant includes a set of amino acid G104S/S107V/A112I/A120V compared to SEQ ID NO: 1; an optional linker, and Fc domain.
EFFECT: invention provides obtainment of hybrid proteins of sPD-1-Fc variants, which bind to and antagonize PD-1 ligands.
38 cl, 42 dwg, 10 tbl, 11 ex
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