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(19)

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2 789 648

(13)

(51)

IPC

C07K16/28(2006-01-01)

C07K16/46(2006-01-01)

C07K19/00(2006-01-01)

C12N15/09(2006-01-01)

A61K39/395(2006-01-01)

A61P29/00(2006-01-01)

A61P35/00(2006-01-01)

A61P37/02(2006-01-01)

(21) (22)

Application

2018128601, 2017-01-11

(24)

Start date

2017-01-11

(22)

Actual filing date

2017-01-11

(45)

Published

2023-02-07

(72)

Inventor

Ekelman Brendan P.Timmer Dzhon K.Khata ChelsiDzhons Kajl S.Khussejn AbrakhimRazai Amir S.Beklund BrajanPandit RadzhajKaplan MajkReskon LukasDevero Kuinn

(73)

Holder

Inkhibrks, Ink.

MULTIVALENT AND MULTI-SPECIFIC 41BB-BINDING FUSED PROTEINS Russian patent published in 2023 - IPC C07K16/28 C07K16/46 C07K19/00 C12N15/09 A61K39/395 A61P29/00 A61P35/00 A61P37/02

Abstract RU 2789648 C2

FIELD: biochemistry.

SUBSTANCE: invention relates to biochemistry, in general, to molecules, which specifically interact with 41BB – a representative of TNF receptor superfamily (hereinafter – TNFRSF), in particular to multivalent and/or multi-specific molecules, which bind at least 41BB. Fused proteins, according to the invention, are capable of enhanced clustering of TNFRSF representatives compared to bivalent antibodies, without crosslinking.

EFFECT: fused proteins, according to the invention, modulate immune cells, and they are suitable for use in the treatment of neoplasms, inflammatory pathological conditions.

16 cl, 25 dwg, 4 ex

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RU 2 789 648 C2

Authors

Ekelman Brendan P.

Timmer Dzhon K.

Khata Chelsi

Dzhons Kajl S.

Khussejn Abrakhim

Razai Amir S.

Beklund Brajan

Pandit Radzhaj

Kaplan Majk

Reskon Lukas

Devero Kuinn

Dates

2023-02-07—Published

2017-01-11—Filed