TRICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS Russian patent published in 2021 - IPC C07D471/16 C07D491/22 C07D498/16 A61K31/53 A61K31/5395 A61P31/18 

FIELD: biochemistry.

SUBSTANCE: invention relates to a compound or a pharmaceutically acceptable salt thereof having Formula (I), in which A is -CH(R²)-; X is a 5-membered monocyclic heteroaryl containing 2 ring heteroatoms representing N, or -N(R⁵)C(O)-; Y is selected from -О-, -N(R⁵)- or -CH(R³)- or -A-Y- is -C(R²)=CH-; Z is -С(=О), -CH(R⁴)- or a bond in such a way that: (i) when Y is -О- or -N(R⁵)-, then Z is -С(=O), (ii) when Y is -CH(R³)-, then Z is a bond or -CH(R⁴), and (iii) when -А-Y- is -C(R²)=CH-, then Z is a bond; R¹ represents a phenyl group which is substituted by 1 to 3 groups, each of which is independently selected from halogen; R² is selected from Н, -O-(C₁-C₆alkyl); R³ is selected from Н; in each case R⁴ is independently selected from Н; in each case R⁵ independently represents Н or C₁-C₆alkyl; R^7A is Н; R^7B is Н or R^7A and R^7B together with their common carbon atom to which they are attached, combine to form a spirocyclic 4-7-membered monocyclic heterocycloalkyl group containing 1 heteroatom, which is O; and R⁸ is selected from C₁-C₆alkyl, -(C₁-С₆alkylene)-О-(С₁-С₆alkyl) and -(C₁-С₆alkylene)-С₃-С₇cycloalkyl. invention also relates to individual compounds, a pharmaceutical composition, a method for inhibiting HIV integrase in a subject, a method for treating HIV infection or treating, preventing or delaying the onset or progression of AIDS in a subject.

EFFECT: new compounds of Formula (I) have been obtained that inhibit HIV integrase and which can find use in the treatment of HIV infection.

(I)

16 cl, 1 tbl, 22 ex