THIOUREA DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS, PHARMACEUTICAL COMPOSITION, METHOD OF INHIBITION OF REVERSE TRANSCRIPTASE OF AIDS Russian patent published in 1998 - IPC

FIELD: medicine and biology. SUBSTANCE: present invention describes thiourea derivatives of formula I or pharmaceutically acceptable salts thereof: (R₅R₆R₈)C-CH(R₉)-NH-(C=S)-NHR₁, wherein R₁ is 5-6 membered heterocycles containing nitrogen, sulfur unsubstituted by C₁-C₄-alkyl, C₁-C₃ alkoxy, CN, OH, CH₃S, NO₂, CF₃, halogen; R₅ is aryl, cycloalkyl, heterocycle; R₆ is hydrogen or methyl; R₈ and R₉ are independently hydrogen or methyl or R₈ and R₉ together with carbon atom to which they are attached are cyclopropyl or cyclobutyl, or R₆ and R₈ together with carbon atom to which they are attached are cyclopropyl. Present invention also describes pharmaceutical composition having inhibitory activity against reversed transcriptase of AIDS including, as the active ingredient, effective amount of derivatives of formula I. EFFECT: improved properties of the pharmaceutical composition. 21 cl, 433 ex, 7 tbl