FIELD: immunology.
SUBSTANCE: proposed is an antibody against VISTA or an antigen-binding fragment thereof, a nucleic acid, an expression vector, a cell. Also proposed is a method for producing an antibody or an antigen-binding fragment thereof, a composition for prevention or treatment, and a composition for simultaneous administration in combination with an antibody against PD-1 or an antibody against PD-L1.
EFFECT: present invention can find further application in therapy of tumors or autoimmune diseases expressing the V-domain Ig-suppressor of T-cell activation (VISTA).
9 cl, 10 dwg, 13 tbl, 13 ex
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