FIELD: biotechnology.
SUBSTANCE: antibody specifically binding to angiopoietin-2 (hereinafter – Ang2) or its antigen-binding fragment are proposed. Nucleic acid encoding this antibody, an expression vector containing nucleic acid, a cell transformed with the vector, and a method for the production of an antibody are also proposed. In addition, the invention relates to options of a composition including an antibody according to the invention. The composition can be intended for the prevention or treatment of a disease related to activation and (or) excessive production of Ang2, for diagnostics of the specified disease, for the treatment of eye diseases, for the prevention or treatment of an oncological disease, for combination with other therapeutic drugs.
EFFECT: invention provides inhibition of Ang2 function.
15 cl, 12 dwg, 14 tbl, 13 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTIBODIES AGAINST VISTA AND APPLICATION THEREOF | 2018 |
|
RU2750723C1 |
| ANTIBODY AGAINST TIE-2 AND ITS USE | 2020 |
|
RU2795455C2 |
| PROGRAMMED CELL DEATH (PD-1) PROTEIN-1 ANTIBODIES AND USE THEREOF | 2017 |
|
RU2725950C1 |
| ANTIBODY AGENTS SPECIFIC TO HUMAN CD19, AND THEIR APPLICATIONS | 2016 |
|
RU2773317C2 |
| ANTI-HER2/ANTI-4-1BB BISPECIFIC ANTIBODY AND USE THEREOF | 2020 |
|
RU2831838C2 |
| BISPECIFIC ANTI-EGFR/ANTI-4-1BB ANTIBODY AND USE THEREOF | 2020 |
|
RU2831836C2 |
| ANTI-DR5 ANTIBODY AND USE THEREOF | 2018 |
|
RU2735956C1 |
| ANTIBODIES AGAINST LIGAND-1 PROGRAMMED DEATH (PD-L1) AND APPLICATION THEREOF | 2017 |
|
RU2721582C1 |
| ANTIBODIES TO HUMAN INTERLEUKIN-2 AND THEIR APPLICATION | 2018 |
|
RU2745451C1 |
| ANTIBODIES AGAINST CXCR2 AND THEIR USE | 2019 |
|
RU2807067C2 |
