FIELD: biotechnology.
SUBSTANCE: antibody specifically binding to angiopoietin-2 (hereinafter – Ang2) or its antigen-binding fragment are proposed. Nucleic acid encoding this antibody, an expression vector containing nucleic acid, a cell transformed with the vector, and a method for the production of an antibody are also proposed. In addition, the invention relates to options of a composition including an antibody according to the invention. The composition can be intended for the prevention or treatment of a disease related to activation and (or) excessive production of Ang2, for diagnostics of the specified disease, for the treatment of eye diseases, for the prevention or treatment of an oncological disease, for combination with other therapeutic drugs.
EFFECT: invention provides inhibition of Ang2 function.
15 cl, 12 dwg, 14 tbl, 13 ex
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