FIELD: biotechnology.
SUBSTANCE: following are presented: an antibody or its antigen-binding fragment that binds to TIE-2 tyrosine-protein kinase receptor and a method for their production, a nucleic acid encoding an antibody or its antigen-binding fragment, an expression vector, a cell transformed with an expression vector to obtain an antibody or its antigen-binding fragment. Also a composition is provided for preventing or treating an angiogenesis-related disease, a composition for stabilizing blood vessels, a composition for diagnosing an angiogenesis-related disease, a composition for preventing or treating cancer, a composition for preventing or treating a tumor, and the use of a composition containing a pharmaceutically effective the amount of the antibody or antigen-binding fragment thereof.
EFFECT: invention makes it possible to obtain an antibody or its antigen-binding fragment that binds to TIE-2 tyrosine-protein kinase receptor, as well as compositions for the prevention or treatment of an angiogenesis-related disease.
16 cl, 18 dwg, 4 tbl, 13 ex
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