FIELD: medicine.
SUBSTANCE: invention relates to peptide-nucleic acid derivatives that interact directionally with a part of the human HIF-1α pre-mRNA. Peptide-nucleic acid derivatives effectively induce exon skipping to produce HIF-1α mRNA splice variants in cells, and they can be used to treat indications or conditions involving HIF-1α overexpression.
EFFECT: producing peptide-nucleic acid derivatives for the treatment of indications or conditions involving HIF-1α overexpression.
11 cl, 13 dwg, 2 tbl, 12 ex
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